Skin barrier in atopic dermatitis: beyond filaggrin

Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors.The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma.Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components…

Continue ReadingSkin barrier in atopic dermatitis: beyond filaggrin

Itchy Dozen Worst Foods for Eczema

In my household we have one vegan, one vegetarian and one meat-eater who is sensitive to salicylates, dairy and soy. It can be difficult when a family member is first diagnosed with eczema and food sensitivities, especially at Christmas. While my daughter no longer has eczema (more on that shortly), I know what it’s like to give up some of the foods you love because they are hurting you. Cooking is more of a chore than normal … until you get the hang of it.…

Continue ReadingItchy Dozen Worst Foods for Eczema

Steroid Withdrawal Effects Long-Term Topical Corticosteroid Use

BACKGROUND: Concerns about topical steroid withdrawal (TSW) are leading some patients to cease long-term topical corticosteroid (TCS) therapy. Diagnostic criteria for this condition do not exist. OBJECTIVE: This study aimed to examine the demographics and outcomes in adult patients who believe they are experiencing TSW following discontinuation of chronic TCS overuse. METHODS: This was a retrospective cohort study of patients in an Australian general practice presenting with this clinical scenario between January 2015 and February 2018. RESULTS: Women represented 56% of the 55 patients seen,…

Continue ReadingSteroid Withdrawal Effects Long-Term Topical Corticosteroid Use

Skin defences point to eczema therapies

Research suggests that the body’s own natural defences could be harnessed in a potential therapy for a common skin condition. The discovery may help create new treatments for atopic eczema, which affects around one in five children and one in 20 adults in the UK. Dermatitis Also called atopic dermatitis or AD, the condition causes distressing itchy lesions that can lead to broken skin with increased susceptibility to infection. It can have a severe impact on people’s lives, work and sleep. Skin Barrier The discovery…

Continue ReadingSkin defences point to eczema therapies

Red Skin Syndrome: Stop The Suffering

A continual avalanche of new and long-suffering “eczema” patients who have found me over the Internet has prompted me to begin a new website and daily blog. The simple fact is that these patients are unique and identifiable through many simple and time-tested methods. They do NOT have eczema but instead are manifesting symptoms of another kind. The doctors that these patients have seen believe that they are treating chronic eczema when indeed they do not recognize that their patients have severe vasodilation and redness…

Continue ReadingRed Skin Syndrome: Stop The Suffering

Clinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions

All patients with symptomatic oral lesions of cGVHD were included in the study. Exclusion criteria were patients with 12 years or less of age, history of allergy to any of the studied medications and patients already under other topical treatment for oral lesions of cGVHD. Patients were randomly assigned between two study groups: one group rinsed with a solution of clobetasol propionate 0.05% associated to nystatin 100,000 UI/mL; and another group rinsed with a solution of dexamethasone 0.1 mg/ml associated to nystatin 100,000 UI/mL. Patients…

Continue ReadingClinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions

Bad eczema flare-ups may be caused by strains of bacteria

Particular strains of Staphylococcus aureus bacteria have been linked to skin irritation in children with eczema, suggesting that the microbes that live on our skin play a role in the disorder. Eczema affects up to 20 per cent of children, periodically causing bouts of dry and itchy skin. The bacterium Staphylococcus aureus, which is commonly found on skin, is particularly prevalent in people with eczema, but its exact role in the condition is unclear. To learn more, Heidi Kong at the National Institutes of Health…

Continue ReadingBad eczema flare-ups may be caused by strains of bacteria

End of content

No more pages to load